Inbred Mice

 

129X1/SvJArc

Product code 129J
JAX stock number 000691
Strain Description Inbred
Coat Colour Chinchilla (Aw/Aw   Oca2P Tyrc-ch/Oca2P Tyrc) and/or albino (Aw/Aw   Oca2P Tyrc/Oca2P Tyrc)
MHC Haplotype H2Kb
Complement Factor C5 normal
  • Used as a research tool in many fields, including cancer research, neurobiology and reproductive biology.
  • A strain widely used for the production of targeted mutations using embryonic stem cell lines.
  • Average breeding performance (small litters).
  • Stumpy tails.
  • Pregnant females litter early if transported pregnant.
  • Progressive hearing loss with onset prior to 3 months of age (homozygous for Cdh23ahl).
  • Eye problems (blindness).
  • See www.jax.org for more strain information.
  • These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: http://jaxmice.jax.org/cou/index.html.

 

129x1SvJ

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A/JArc

Product code AJ
Strain Description Inbred
Coat Colour Albino (a/a Tyrp1b/Tyrp1b Tyrc/Tyrc)
MHC Haplotype H2Ka
Complement Factor C5 deficient
  • Used in research on CD antigens, antigen receptors and histocompatibility markers.
  • Poor breeding performance (small litters).
  • High social dominance of males in competition for females.
  • High spontaneous incidence of lung adenomas and mammary tumours in   breeding females.
  • Congenital defects include cleft-lip/palate and polydactyly at a prevalence of up to 10%.
  • Incidence of nephritis and amyloidosis nearly 100% at 15 months.
  • Low aggression, low responder in general (activity, alcohol, anaesthetics, metabolism).
  • Hearing loss, blindness.

AJ

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BALB/cArc

Product code BC
Strain Description Inbred
Coat Colour Albino (A/A Tyrp1b/Tyrp1b Tyrc/Tyrc)
MHC Haplotype H2Kd
Complement Factor C5 normal
  •   Good breeding performance.
  •   Low incidence of mammary tumours.
  •   Amyloidosis (40%) in older males.
  •   Slightly aggressive from 7 weeks of age.
  •   High social dominance exhibited by males in presence of females resulting in high agression
  •   Low mortality after neonatal thymectomy.
  •   Cystitis.
  •   Occurrence of divided septums.
  •   Barbering from 7 weeks.

BALB/c

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C3H/HeJArc

Product code C3H
JAX stock number 000659
Strain Description Inbred
Coat Colour Agouti (A/A)
MHC Haplotype H2Kk
Complement Factor C5 normal
  • Used as a general purpose strain in a wide variety of research areas including cancer, infectious disease, sensorineural, and cardiovascular biology research.
  • Blindness by weaning age.
  • High incidence of hepatomas.
  • Average breeding performance.
  • Typically C3H/HeJArc are unresponsive to lipopolysaccharide (LPS) due to a B-cell deficiency (Anderson and Ostermann, 1980).
  • Highly susceptible to infection by Gram negative bacteria.
  • Spontaneous corneal opacities.
  • Retina lack photoreceptors.
  • Hearing normal.
  • Alopecia areata.
  • Cardiac mineralisation/calcinosis.
  • See www.jax.org for more strain information.
  • These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: http://jaxmice.jax.org/cou/index.html.

C3H/HeJ

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C57BL/6JArc

Product code B6
JAX stock number 000664
Strain Description Inbred
Coat Colour Black (a/a)
MHC Haplotype H2Kb
Complement Factor C5 normal
  • Good breeding performance.
  • Susceptible to the development of atheromatous lesions after 20 weeks on high fat diets.
  • Develops non-insulin dependent diabetes mellitus and hypertension when fed a high/fat, high simple-carbohydrate diet.
  • Glucose intolerance is due to spontaneous mutation in Nicotinamide Nucleotide Transhydrogenase (Nnt).
  • Generally refractory to many tumours and to many infectious agents.
  • Congenital abnormalities include microphthalmia, corneal opacities, anophthalmia and hydrocephalus (Smith, R.S., Roderick, T.H. and Sundberg, J.P., 1994).
  • Susceptible to imperforate vaginas and mucometra.
  • White spotting commonly observed in pigmentation.
  • Aggressiveness observed in male stock from 6 weeks of age and female breeders.
  • Fighting amongst males increases when cohorts are divided intosm aller groups.
  • Barbering and ulcerative dermatitis observed.
  • See www.jax.org for more strain information.
  • These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: http://jaxmice.jax.org/cou/index.html.

C57BL/6J

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C57BL/10ScSnArc

Product code B10
Strain Description Inbred
Coat Colour Black (a/a)
MHC Haplotype H2Kb
  • Average breeding performance. Best mating scheme 1:1
  • High incidence of spontaneous deviants (possible mutants).
  • High degree of genetic distinctiveness.
  • Primarily a genetic “tool” strain.
  • The most commonly used strain for development of resistant congenic lines differing from the parental strain by single histocompatibility loci.
  • Divided septums observed.
  • Congenital abnormalities include microphthalmia, corneal opacities and hydrocephalus.
  • Barbering common.

C57BL10/ScSn

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CBA/CaHArc

Product code CBA
Strain Description Inbred
Coat Colour Agouti (A/A)
MHC Haplotype H2Kk
Complement Factor C5 normal
  • Good breeding performance.
  • Low activity and docile.
  • High overall tumour incidence, including hepatomas and mammary tumours.
  • Resistant to the induction of atherosclerosis by high fat diet.
  • Widely distributed as a general purpose strain.
  • Considerable variation between sublines, thus care must be exercised in comparing CBA subline data.
  • High rate of spontaneous mutations.

CBA/CaHArc

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DBA/1JArc

Product code DB1
JAX stock number 000670
Strain Description Inbred
Coat Colour Dilute brown (a/a Tyrp1b/Tyrp1b Myo5ad/Myo5ad)
MHC Haplotype H2Kq
Complement Factor C5 normal
  • Poor breeding performance (average litter size).
  • High incidence of chronic degenerative lesions in heart muscle of old animals.
  • Low gross tumour incidence, especially in males.
  • High incidence of lymphoma and lung tumours in some studies.
  • Aggressive.
  • See www.jax.org for more strain information.
  • These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: http://jaxmice.jax.org/cou/index.html.

DBA/1JArc

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DBA/2JArc

Product code DB2
JAX stock number 000671
Strain Description Inbred
Coat Colour Dilute brown (a/a Tyrp1b/Tyrp1b Myo5ad/Myo5ad)
MHC Haplotype H2Kd
Complement Factor C5 deficient
  • Poor breeding performance.
  • High incidence of sterility.
  • High incidence of spontaneous calcification of the heart muscle in older mice.
  • Low blood pressure, high red blood count.
  • Active and aggressive.
  • Intolerance to ethanol.
  • Susceptible to audiogenic seizures (begins at 2 weeks, peaks at 3 weeks,  gradually declines with age).
  • Progressive hearing loss.
  • Generally susceptible to infectious agents.
  • Eye abnormalities (glaucoma, corneal mineralisation).
  • See www.jax.org for more strain information.
  • These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: http://jaxmice.jax.org/cou/index.html.
OLYMPUS DIGITAL CAMERA

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FVB/NJArc

Product code FVB
JAX stock number 001800
Strain Description Inbred
Coat Colour Albino (A/A Tyrc/Tyrc)
MHC Haplotype H2Kq
Complement Factor C5 deficient
  • Good breeding performance (large litters).
  • Useful for production of transgenic mice as fertilised eggs contain large and prominent pronuclei, which facilitates microinjections.
  • Aggressive, especially female stock from 6 weeks of age.
  • May get lung tumours but low incidence of lymphomas.
  • Neuropathological conditions in some sublines, showing seizures and neuronal necrosis in cerebral cortical and hippocampal neurons (not observed in ARC colony for a few years now).
  • See www.jax.org  for more strain information.
  • These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: http://jaxmice.jax.org/cou/index.html.

FVB/NJArc

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NOD/ShiLtJArc

Product code NOD
JAX stock number 001976
Strain Description Inbred
Coat Colour Albino (A/A Tyrc/Tyrc)
MHC Haplotype H2Kg7
Complement Factor C5 deficient
  • Strain was formerly called NOD/LtJ until 2007 when it was changed to NOD/ShiLtJ.
  • This strain is used in immunology and inflammation research and is a polygenic model for type 1 diabetes.
  • The Jackson Laboratory reports that diabetes occurs in 90-100% of females by 30 weeks of age and 40-60% of males by 30-40 weeks of age.
  • Susceptibility to diabetes is polygenic and environment factors such as housing conditions, health status and diet exert a strong effect on penetrance.
  • Good breeding performance but a high mortality is observed in breeders.
  • Females produce 4 to 5 litters before becoming diabetic.
  • Female breeders are aggressive.
  • The incidence of diabetes in males is influenced by environmental factors including pathogens in an inverse relationship i.e. higher incidence of diabetes in germfree animals than conventional animals. Please contact info@arc.wa.gov.au for more information.
  • Mice free from diabetes by 1 year are prone to develop follicle centre cell lymphomas.
  • See www.jax.org for more strain information.
  • These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: http://jaxmice.jax.org/cou/index.html.

NOD Lt

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SJL/JArc

Product code SJL
JAX stock number 000686
Strain Description Inbred
Coat Colour Albino (Oca2p Tyrc/Oca2p Tyrc A/A)
MHC Haplotype H2Ks
Complement Factor C5 normal
  • Good model for limb girdle muscular dystrophy.
  • SJL/JArc mice are immunocompetent but have elevated levels of circulating T cells.
  • Average breeding performance.
  • High incidence of type B reticulum cell sarcomas.
  • High incidence of spontaneous amyloidosis.
  • Sensitive to immune tolerance induction at birth but by two months becomes resistant to tolerance induction.
  • Stock males are very aggressive.
  • See www.jax.org for more strain information.
  • These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: http://jaxmice.jax.org/cou/index.html.

SJL J

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