Mutant Mice

BALB/c-Foxn1nu/Arc

Product code BCNU
Strain Description Mutant inbred
Coat Colour Albino (A/A Tyrp1b/Tyrp1b Tyrc/Tyrc).Haired when heterozygous, nude when homozygous.
MHC Haplotype H2Kd
Complement Factor C5 normal
  • Good breeding performance (refer to BALB/c).
  • Nude is an autosomal recessive mutation located on chromosome 11.
  • Foxn1nu – autosomal recessive Forkhead box N1.
  • Typically, litters consist of equal nude and haired offspring.
  • Preweaner nudes are not as robust as heterozygous littermates and are prone to heat loss, dehydration and slower weight gains, hence they should not be weaned before 4 weeks of age.
  • Prone to dust in their eyes as no eyelashes.
  • Homozygotes are athymic.
  • Female nu/+ prone to cystitis.
  • High Incidence of divided septums.
  • The two major defects are failure of hair growth and dysgenesis of thymic epithelium due to developmental failure of the thymic anlage arising from the 3rd pharyngeal pouch. The defect lies in the thymic epithelium, there being no intrinsic defect in T cell precursors. Nude mice respond poorly to thymus-dependent antigens because of a defect in helper T-cell activity. Responses to thymus-independent antigens are normal. Normal or increased NK cell activity is present.
  • Housed in an isolator – immunodeficient.

BALB/c nude

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C57BL/10ScSn-Dmdmdx/Arc
Product code MDX
Strain Description Mutant inbred
Coat Colour Black (a/a)
MHC Haplotype H2Kb
  • Average breeding performance (refer to C57BL/10ScSnArc).
  • Dmdmdx – sex linked recessive (Duchenne muscular dystrophy.
  • Muscular dystrophy not observed.
  • Cystitis and divided septums observed.
  • Congenital abnormalities include microphthalmia, corneal opacities and hydrocephalus.
  • Mice behave normally despite muscle pathology.

 

C57BL10/ScSn

 

 

 

 

 

 

 

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C.B-17/IcrHanHsdArcPrkdcscid
Product code SCID
Strain Description Mutant inbred
Coat Colour Albino (A/A Tyrp1b/Tyrp1b Tyrc/Tyrc)
MHC Haplotype H2Kd
Complement Factor C5 normal
  • Average breeding performance.
  • Arose as a spontaneous autosomal recessive mutation in C.B-Igh-1b (CB-17) congenic strain. Prkdcscid (autosomal recessive, protein kinase, DNA activated, catalytic polypeptide).
  • Homozygotes have little or no immunoglobulin in serum. Lymphoid organs consist of vascular connective tissue and macrophages and are devoid of lymphocytes.
  • Bone marrow lacks plasma cells and lymphocytes and skin lacks dendritic Thy-1+ epidermal cells. Although B and T-cells and pre-B and pre-T cells are absent early B and T-cells are present.
  • A variable percentage (2-20%) of young adults develops low numbers of functional B and T-cells. This is not genetically determined.
  • Macrophage activation and antigen presentation, NK cell activity and myeloid cell differentiation is normal.
  • Useful model for studying the relationship between immunity and disease, studies on engraftment of xenogenic cells and tissues and studying human severe combined immunodeficiency.
  • Also a useful model for understanding the basis of increased lymphoid malignancies in immunodeficiencies as thymic lymphomas occurs in about 15% of mice.
  • Cystitis in female stock.
  • Housed in an isolator.

 

scid

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NOD.CB17-Prkdcscid/Arc
Product code NODSCID
Strain Description Mutant inbred
Coat Colour Albino (A/A Tyrc/Tyrc)
MHC Haplotype H2Kg7
Complement Factor C5 deficient
  • The Animal Resources Centre received breeding pairs from colonies held at the Walter and Eliza Hall Institute in December 1998.
  • Average breeding performance (high mortality in breeders; aggressive).
  • Refer to NOD/ShiLtJArc.
  • Prkdcscid – autosomal recessive, protein kinase, DNA activated, catalytic polypeptide.
  • No endogenous T- or B- lymphocyte function.
  • Develops high incidence of thymoma with age and old mice can develop inclusion body nephropathy.
  • Used for the delineation of the role of T cell subsets and auto-antibodies in diabetes.
  • Housed in an isolator.
  • Often used as the ‘control’ for NOD/ShiLtJArc.

NOD SCID