Induced Mutant Mice

(Transgenic and Targeted-Mutant Mice)

C57BL/6J-TgN(A2KbHLA)6HsdArc

Product code A2KB
Strain Description Transgenic
Coat Colour Dark grey
MHC Haplotype H2Kb
Complement Factor C5 normal
  • Transgenic for HLA A2Kb gene.
  • Congenital abnormalities include microphthalmia, corneal opacities, anophthalmia and hydrocephalus.
  • Average breeding performance.
  • Litters lost at approximately 17 days.
  • High fat diet prevents loss of litters.
  • Refer to C57BL/6JArc for background strain information.

A2Kb

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B6.129P2-Apoe tm1Unc/JArc

Product code APOE
JAX stock number 002052
Strain Description Mutant inbred
Coat Colour Black (a/a)
MHC Haplotype H2Kb
Complement Factor C5 normal
  • Average breeding performance.
  • Mice homozygous for the Apoetm1Unc  mutation show a marked increase in total plasma cholesterol levels that are unaffected by age or sex.
  • Divided septums prone in females.
  • Fatty streaks in the proximal aorta are found at 3 months of age. The lesions increase with age and progress to lesions with less lipid but more elongated cells, typical of a more advanced stage of pre-atherosclerotic lesion.
  • Moderately increased triglyceride levels have been reported in mice with this mutation on a mixed C57BL/6 x 129 genetic background.
  • Aged apoE-deficient mice (>17 months) have been shown to develop xanthomatous lesions in the brain consisting mostly of crystalline cholesterol clefts, lipid globules, and foam cells. Smaller xanthomas were seen in the choroid plexus and ventral fornix.
  • Recent studies indicate that apoE-deficient mice have altered responses to stress, impaired spatial learning and memory, altered long term potentiation, and synaptic damage.
  • See www.jax.org for more strain information.
  • These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: http://jaxmice.jax.org/cou/index.html.

APOE

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B6.SVJ129-Rag1tm1Bal/Arc

Product code RAG1
Strain Description Mutant inbred
Coat Colour Agouti.
MHC Haplotype H2Kb
Complement Factor C5 normal
  • Agouti N6 and black N10 mice available.
  • Good breeding performance.
  • Housed in an isolator.
  • Mice homozygous for the Rag1tm1Bal  mutation produce no mature T cells or B cells.
  • Their phenotype can be described as a “non-leaky” severe combined immune deficiency (Prkdcscid/Prkdcscid). Prkdcscid mice produce some B cells and IgM.
  • They have no CD3+ or T cell receptor (TCR) alpha-beta positive cells.
  • The thymus of the mutant mice contains 15 to 130 times fewer cells than heterozygous or wildtype siblings.
  • The thymocytes are CD8CD4 and most are IL2 receptor positive.
  • Neither the spleen nor bone marrow contain any IgM or IgD staining cells, indicating an absence of mature B cells.
  • These and other data suggest that B cell and T cell development has been arrested at an early stage.
  • Macroscopically, the mutants are indistinguishable from heterozygotes or normal wildtype siblings.
  • Old mice can develop inclusion body nephropathy.

RAG 1 KO