Inbred Rats

BN/RijHsdArc

Product code BN
Strain Description Inbred
Coat Colour Brown (a, b, C, hi):
MHC Haplotype RT1n
  • Poor to moderate breeding performance.
  • Low post-partum mating frequency.
  • Hydronephrosis and hydroureter common.
  • Endocardial disease in older animals.
  • High incidence of urinary bladder and ureteral carcinomas in old males.
  • Moderate incidence of pituitary adenomas in older animals
  • Immunologic model as the strain is unique in its expression of the high lgE – responder phenotype.
  • Resistant to experimental allergic encephalomyelitis.
  • Resistant to induction of autologous immune complex glomerulonephritis.

BN

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DA/Arc

Product   code

DA

Strain   Description

Inbred

Coat   Colour

Agouti   (A,B,C, H)

MHC   Haplotype

RT1av1

  • Good breeding performance.
  • Uses include studies on transplantable salivary gland adenocarcinomas, transplantation immunology, autoimmune disease (eg. thyroiditis).
  • Occasional hydrocephalus.

DA

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F344/Arc

Product code F344
Strain Description Inbred
Coat Colour Albino (a, B, c, h):
MHC Haplotype RT1lv1
  • Good breeding performance.
  • Interstitial cell tumours of the testis.
  • Resistant to spontaneous autoimmune thyroiditis.
  • Low incidence of nephritis.
  • The most popular strain of rat for use in carcinogen evaluation, due to relatively low incidence of naturally occurring neoplasms but a relatively high responder to induced neoplasms via chemicals and/or irradiation.
  • Young females are jumpy and don’t like being handled.

F344

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LEW/CrlArc

Product code LEW
Strain Description Inbred
Coat Colour Albino (a, B, c, h)
MHC Haplotype RT1l
  • Good breeding performance.
  • Docile.
  • Susceptible to induction of experimental allergic encephalomyelitis, adjuvant induced arthritis, induced autoimmune myocarditis and autologous immune complex glomerulonephritis.
  • Host for a number of induced neoplasms (lymphoma 8,renal sarcoma, fibrosarcomas).

LEWIS

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PVG/CArc

Product code PVG
Strain Description Inbred
Coat Colour Black hooded (a, B, C, h)
MHC Haplotype RT1c
  • Very good breeding performance; docile.
  • Popular inbred for general use as low activity relative to other strains.
  • Resistant to experimental allergic encephalomyelitis and the induction of autoimmune thyroiditis.
  • Useful model for development of autoimmune thyroiditis and diabetes due to insulitis following thymectomy and sublethal x-irradiation.

PVGc

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SHR/NCrlArc

Product code SHR
Strain Description Inbred
Coat Colour Albino (c)
MHC Haplotype RT1k
  • Poor breeding performance.
  • Blood pressure measured as part of Phenotype Management Plan.
  • Blood pressure of 150-160mm Hg by 10 weeks of age in males and females.
  • High incidence of periarteritis nodosa autoimmune in origin, myocardial infarctions, nephrosclerosis, lymphopaenia and variable incidence of cerebral lesions relative to the degree of hypertension.
  • Aggressive.

SHR

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WKY/NCrlArc

Product code WKY
Strain Description Inbred
Coat Colour Albino (a, B, c, h)
MHC Haplotype RT1l
  • Good breeding performance.
  • Adult WKY have an inability to excrete acid appropriately after acute or chronic acid loading compared to Sprague Dawley rats.
  • A subset of WKY originating at NIH demonstrates an inheritable transmission of biventricular cardiac hypertrophy (BVH).
  • WKY with BVH provide a natural model of volume load hypertrophy.
  • Recognised normotensive control to use in parallel with studies involving the hypertensive SHR rat.

WKY